Sometime ago I needed some basic math in Minion and I concocted something
like follows below:

% latin
\definefallbackfamily [mainface] [math] [Minion Pro]
[preset=math:mathematicalalphanumericsymbols,force=yes]
\definefallbackfamily [mainface] [math] [Minion Pro]
[preset=math:mathematicalalphanumericsymbols,range={1D50D,1D514},force=yes]
\definefallbackfamily [mainface] [math] [Minion Pro]
[preset=math:miscellaneousmathematicalsymbolsa,force=yes]
\definefallbackfamily [mainface] [math] [Minion Pro]
[preset=math:miscellaneousmathematicalsymbolsb,force=yes]
\definefallbackfamily [mainface] [math] [Minion Pro]
[preset=math:lowercasenormal,force=yes]
\definefallbackfamily [mainface] [math] [Minion Pro]
[preset=math:uppercasenormal,force=yes]
\definefallbackfamily [mainface] [math] [Minion Pro]
[preset=math:lowercaseitalic,force=yes]
\definefallbackfamily [mainface] [math] [Minion Pro]
[preset=math:uppercaseitalic,force=yes]
\definefallbackfamily [mainface] [math] [Minion Pro]
[preset=math:lowercasebold,force=yes]
\definefallbackfamily [mainface] [math] [Minion Pro]
[preset=math:uppercasebold,force=yes]
\definefallbackfamily [mainface] [math] [Minion Pro]
[preset=math:lowercasebolditalic,force=yes]
\definefallbackfamily [mainface] [math] [Minion Pro]
[preset=math:uppercasebolditalic,force=yes]

% greek
\definefallbackfamily [mainface] [math] [Minion Pro]
[preset=math:lowercasegreeknormal,force=yes]
\definefallbackfamily [mainface] [math] [Minion Pro]
[preset=math:uppercasegreeknormal,force=yes]
\definefallbackfamily [mainface] [math] [Minion Pro]
[preset=math:lowercasegreekitalic,force=yes]
\definefallbackfamily [mainface] [math] [Minion Pro]
[preset=math:uppercasegreekitalic,force=yes]
\definefallbackfamily [mainface] [math] [Minion Pro]
[preset=math:lowercasegreekbold,force=yes]
\definefallbackfamily [mainface] [math] [Minion Pro]
[preset=math:uppercasegreekbold,force=yes]
\definefallbackfamily [mainface] [math] [Minion Pro]
[preset=math:lowercasegreekbolditalic,force=yes]
\definefallbackfamily [mainface] [math] [Minion Pro]
[preset=math:uppercasegreekbolditalic,force=yes]

% digits - need to be defined without node mode, which means no default set
\definefontfeature[inlinemath][lnum=yes,pnum=yes]
\definefallbackfamily [mainface] [math] [Minion Pro]
[preset=math:digitsnormal,features=inlinemath,force=yes]
\definefallbackfamily [mainface] [math] [Minion Pro]
[preset=math:digitsbold,features=inlinemath,force=yes]
\definefallbackfamily [mainface] [math] [Minion Pro]
[superscriptsandsubscripts] [force=yes]
\setupmathematics[autopunctuation={all},ucgreek=italic,lcgreek=italic]

\definefallbackfamily [mainface] [math] [Minion Pro]
[tf=style:normal,range={0x27-0x2F,0x3C-0x3E,0xB1,0xD7,0xF7,0x3E,0x5B-0x5D,0x7B-0x7E,0x2111,0x1D50D,0x2128,0x2190,0x2192,0x210C-0x211C,0x212D,0x2202,0x2206,0x220F,0x2211,0x2212,0x2215,0x2219,0x221E,0x2248,0x2260,0x2264,0x2265,0x27E6-0x27E9,0x1D504-0x1D52F,0x2980}]%

\definefallbackfamily [mainface] [math] [Minion Pro]
[bf=style:bold,range={0x27-0x2F,0xD7,0xF7,0x3A-0x3C,0x3E,0x5B-0x5D,0x7B-0x7E,0x2111,0x1D50D,0x2128,0x210C-0x211C,0x212D,0x2212,0x27E6-0x27E9,0x1D504-0x1D52F,0x2980}]

\definefontfamily [mainface] [math] [Cambria Math]

\setupbodyfont[mainface,12pt]

\starttext

\startformula
c^2 = a^2 + b^2
\stopformula

\bgroup\bf
\startformula
c^2 = a^2 + b^2
\stopformula
\egroup

\startformula
\cos (\gamma) = \Alpha \Gamma \Pi\sin (\alpha)
\stopformula

\bgroup\bf
\startformula
\cos (\gamma) = \Alpha \Gamma \Pi\sin (\alpha)
\stopformula
\egroup

\startformula
\[x\] - |y| + x^2 + y^2 -k² ≤ z^2; \quad \sin(\alpha)^2 + \cos(\beta)^2 = 1.
\stopformula

\bgroup\bf
\startformula
\[x\] - |y| + x^2 + y^2 -k² ≤ z^2; \quad \sin(\alpha)^2 + \cos(\beta)^2 = 1.
\stopformula
\egroup

\startformula
C^2 ≈ A^2 ∫ (B^2 ± \Theta \sin \gamma x) dx = \lim Z → ∞
\stopformula

\bgroup\bf
\startformula
C^2 ≈ A^2 ∫ (B^2 ± \Theta \sin \gamma x) dx = \lim Z → ∞
\stopformula
\egroup

\startformula
\sqrt{34×y\frac{21\alpha^2}{98.0 x_2}}Δθ = \sin(a)^2 + \cos(b)^2
\stopformula

\bgroup\bf
\startformula
\sqrt{34×y\frac{21\alpha^2}{98.0 x_2}}Δθ = \sin(a)^2 + \cos(b)^2
\stopformula
\egroup

\stoptext