I had to rename CAMBRIA.TTC to cambria.ttc, now mtxrun lists the same features.
Perhaps a luatex problem?

Tlig now works, but with Cambria ligatures i had no luck yet with following testfile:
---------------------
\definefontfeature[default][default][script=latn,language=dflt]
\font\cambria=name:cambriabook*default at 12pt
\font\fertigo=name:fertigoproregular*default at 11pt
\starttext
\cambria
-- --- ff fi fl ffi ffl – — ff fi fl ffi ffl
\blank
\fertigo
-- --- ff fi fl ffi ffl – — ff fi fl ffi ffl
\stoptext
---------------------

Greetings Lutz

2009/3/4 Hans Hagen <pragma@wxs.nl>
Wolfgang Schuster wrote:
On Wed, Mar 4, 2009 at 4:35 PM, Hans Hagen <pragma@wxs.nl> wrote:
Lutz Haseloff wrote:

I can't enable fontfeatures for the "Vista-Fonts" for instance Cambria.
They are simply ignored. They are OTF with TTF extensions, ist this
the reason?
mtxrun --script font --list --info cambria
lists a whole lot; but in cambria there is no dflt, dflt so you need to be
explitly latn (because there is also grek and math)

Weird, that's all I get for Cambria (other fonts show the complete list)

Rover:base wolf$ mtxrun --script font --list --info cambria
MtxRun | fontname: cambria
MtxRun | fullname: Cambria
MtxRun | filename: /Users/wolf/Library/Fonts/CAMBRIA.TTC
MtxRun |

maybe an old cambria