\setuplayout
  [
      cutspace=12em,
      leftmargin=2em,
      width=middle,
      backspace=8em,
      rightmargin=24em
    ]


\startsetups[paragraph:hinweis]
  \setuplayout
    [
      cutspace=2em,
      leftmargin=24em,
      backspace=8em,
      rightmargin=2em
    ]
  
\stopsetups

\defineparagraph[hinweis] [paragraph] []
\setupparagraph[hinweis] [color=red,setups=paragraph:hinweis]
\showframe
\starttext
\input knuth

\startparagraph[hinweis]
\input lorem
\stopparagraph

\input knuth

\stoptext