New comment by ericonr on void-packages repository https://github.com/void-linux/void-packages/pull/28965#issuecomment-783219549 Comment: For cross you need to pass `--sysroot` and `--target` to clang. You will find the values of those flags in the `python3-pyside2` template. For i686, it's apparently missing some flag to allow the usage of whatever SIMD it wants.