There is an updated pull request by TinfoilSubmarine against master on the void-packages repository

https://github.com/TinfoilSubmarine/void-packages python3-openssl
https://github.com/void-linux/void-packages/pull/35795

python3-openssl: update to 22.0.0.
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#### Testing the changes
- I tested the changes in this PR: **YES** (tested with synapse)

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I had to do the same thing I did for Twisted--drop the python3 subpackage from python-openssl since versions >21.0.0 don't support python2 anymore.

Dependents to test:
- [ ] gajim
- [ ] impacket
- [x] python3-Twisted
- [x] python3-TxSNI
- [ ] python3-acme
- [ ] python3-josepy
- [ ] python3-nbxmpp
- [ ] python3-ndg_httpsclient
- [x] python3-saml2
- [ ] ripe-atlas-tools
- [x] synapse
- [ ] yubikey-manager

A patch file from https://github.com/void-linux/void-packages/pull/35795.patch is attached