There is a new pull request by sgn against master on the void-packages repository https://github.com/sgn/void-packages python3-grpcio-fix-boringssl https://github.com/void-linux/void-packages/pull/28816 python3-grpcio: correct asm for boringssl The line was changed to: if BUILD_WITH_BORING_SSL_ASM and not BUILD_WITH_SYSTEM_OPENSSL: --- I'm not sure if we should switch to use system's {open,libre}ssl instead of bundled boringssl. Also `re2-devel`. A patch file from https://github.com/void-linux/void-packages/pull/28816.patch is attached